To make this work, you have to be able to create e-mail accounts. You need one e-mail account for Major Major itself, plus one per list that you host. This means that you need to have access to an e-mail server. You can install an e-mail server such as Weasel on your own computer. Alternatively, you can use the e-mail server of your ISP or other mail provider, and ask that provider to create the appropriate accounts.
If you want to see Major Major working in practice, you can join the Major Major discussion list. The way to do this is to send mail to majormajor@os2voice.org with a message saying
subscribe majormajor-list
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