Cytogenetic location: 13q32 Genomic coordinates (GRCh38) : 13:94,400,001-101,100,000
For a phenotypic description and a discussion of genetic heterogeneity of systemic lupus erythematosus, see 152700.
Xing et al. (2005) performed a genomewide scan in 64 multiplex SLE families with at least 1 affected male member and found the largest signal (lod score = 3.08) at 13q32 in 18 African American families. Multipoint model-based linkage analysis generated a lod score of 3.13 in the same chromosomal region. Fine mapping in these 18 families and 3 additional African American families with an affected male member localized the locus to a region tightly linked to the marker D13S892.
Xing, C., Gray-McGuire, C., Kelly, J. A., Garriott, P., Bukulmez, H., Harley, J. B., Olson, J. M. Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum. Genet. 118: 309-321, 2005. [PubMed: 16189706, related citations] [Full Text]
DO: 9074;
Cytogenetic location: 13q32 Genomic coordinates (GRCh38) : 13:94,400,001-101,100,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 13q32 | {Systemic lupus erythematosus, susceptibility to, 5} | 609903 | 2 |
For a phenotypic description and a discussion of genetic heterogeneity of systemic lupus erythematosus, see 152700.
Xing et al. (2005) performed a genomewide scan in 64 multiplex SLE families with at least 1 affected male member and found the largest signal (lod score = 3.08) at 13q32 in 18 African American families. Multipoint model-based linkage analysis generated a lod score of 3.13 in the same chromosomal region. Fine mapping in these 18 families and 3 additional African American families with an affected male member localized the locus to a region tightly linked to the marker D13S892.
Xing, C., Gray-McGuire, C., Kelly, J. A., Garriott, P., Bukulmez, H., Harley, J. B., Olson, J. M. Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum. Genet. 118: 309-321, 2005. [PubMed: 16189706] [Full Text: https://doi.org/10.1007/s00439-005-0061-5]
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