Alternative titles; symbols
Lardi et al. (1994) described 3 Saudi sibs, 2 girls and a boy, with clinical features of chronic myelocytic leukemia in early infancy. Their parents were first cousins. Peripheral blood counts of the parents and available relatives were normal and there was no family history of leukemia. A familial form of CML (608232) that closely resembles the juvenile type, which lacks the Philadelphia chromosome, had previously been reported in at least 3 family sets (Anderson, 1951; Holton and Johnson, 1968). The Philadelphia chromosome was absent in all 3 children reported by Lardi et al. (1994). The short survival of the first 2 children (18 and 2 months, respectively) favored a diagnosis of leukemia rather than leukemoid reaction. The possibility of viral or other infection being responsible for familial clustering was mentioned.
Anderson, R. C. Familial leukemia. A report of leukemia in five siblings, with a brief review of the genetic aspects of this disease. Am. J. Dis. Child 81: 313-322, 1951.
Holton, C. P., Johnson, W. W. Chronic myelocytic leukemia in infant siblings. J. Pediat. 72: 377-383, 1968. [PubMed: 5237795, related citations] [Full Text]
Lardi, A. A., Taha, O. M. A., Al-Jefri, A., Ahmed, M. A. M. Familial chronic myelocytic leukaemia-like syndrome probably of congenital origin. Acta Paediat. 83: 558-560, 1994. [PubMed: 8086739, related citations] [Full Text]
Alternative titles; symbols
DO: 0060761;
Lardi et al. (1994) described 3 Saudi sibs, 2 girls and a boy, with clinical features of chronic myelocytic leukemia in early infancy. Their parents were first cousins. Peripheral blood counts of the parents and available relatives were normal and there was no family history of leukemia. A familial form of CML (608232) that closely resembles the juvenile type, which lacks the Philadelphia chromosome, had previously been reported in at least 3 family sets (Anderson, 1951; Holton and Johnson, 1968). The Philadelphia chromosome was absent in all 3 children reported by Lardi et al. (1994). The short survival of the first 2 children (18 and 2 months, respectively) favored a diagnosis of leukemia rather than leukemoid reaction. The possibility of viral or other infection being responsible for familial clustering was mentioned.
Anderson, R. C. Familial leukemia. A report of leukemia in five siblings, with a brief review of the genetic aspects of this disease. Am. J. Dis. Child 81: 313-322, 1951.
Holton, C. P., Johnson, W. W. Chronic myelocytic leukemia in infant siblings. J. Pediat. 72: 377-383, 1968. [PubMed: 5237795] [Full Text: https://doi.org/10.1016/s0022-3476(68)80211-2]
Lardi, A. A., Taha, O. M. A., Al-Jefri, A., Ahmed, M. A. M. Familial chronic myelocytic leukaemia-like syndrome probably of congenital origin. Acta Paediat. 83: 558-560, 1994. [PubMed: 8086739] [Full Text: https://doi.org/10.1111/j.1651-2227.1994.tb13080.x]
Dear OMIM User,
To ensure long-term funding for the OMIM project, we have diversified our revenue stream. We are determined to keep this website freely accessible. Unfortunately, it is not free to produce. Expert curators review the literature and organize it to facilitate your work. Over 90% of the OMIM's operating expenses go to salary support for MD and PhD science writers and biocurators. Please join your colleagues by making a donation now and again in the future. Donations are an important component of our efforts to ensure long-term funding to provide you the information that you need at your fingertips.
Thank you in advance for your generous support,
Ada Hamosh, MD, MPH
Scientific Director, OMIM