Skip to main content
NCBI home page
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.
Learn more: PMC Disclaimer | PMC Copyright Notice
[画像:The Journal of Clinical Investigation logo]
. 1975 May;55(5):881–891. doi: 10.1172/JCI108016

Evidence that histidine is an essential amino acid in normal and chronically uremic man.

J D Kopple , M E Swendseid
PMCID: PMC301830 PMID: 1123426

Abstract

The requirement for dietary histidine was investigated in four normal and three chronically uremic men. Subjects lived in a metabolic unit where they were fed three isonitrogenous diets in the following order: a 40-g protein diet (28 plus or minus SD 8 days), a semi-synthetic amino acid diet deficient in histidine (35 plus or minus 2 days), and an amino acid diet which contained histidine (31 plus or minus 5 days). With ingestion of the histidine-deficient diet, nitrogen balance gradually became negative, and serum albumin decreased in six subjects. Plasma histidine fell by 82 plus or minus 6 per cent; muscle histidine decreased by 62 plus or minus 19 per cent; the hematocrit fell by 25 plus or minus 9 per cent; and serum iron rose. Subjects felt unwell, and in five cases a skin lesion consisting of fine scales, dry skin, and mild erythema developed. After administration of the histidine-repletion diet, nitrogen balance became positive in six subjects; serum albumin increased in five cases; plasma and muscle histidine rose; serum iron fell abruptly; a reticulocytosis ensued; and the hematocrit rose. The clinical symptoms and skin lesions disappeared. These observations indicate that histidine is an essential amino acid in normal and chronically uremic man. The absence of dietary histidine is associated with failure of normal erythropoiesis.

Full text

PDF
[画像:881]

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson H. L., Linkswiler H. Effect of source of dietary nitrogen on plasma concentration and urinary excretion of amino acids of men. J Nutr. 1969 Sep;99(1):91–100. doi: 10.1093/jn/99.1.91. [DOI] [PubMed] [Google Scholar]
  2. Bergström J., Fürst P., Josephson B., Norée L. O. Improvement of nitrogen balance in a uremic patient by the addition of histidine to essential amino acid solutions given intravenously. Life Sci II. 1970 Jul 22;9(14):787–794. doi: 10.1016/0024-3205(70)90083-4. [DOI] [PubMed] [Google Scholar]
  3. Bergström J., Fürst P., Josephson B., Norée L. O. Improvement of nitrogen balance in a uremic patient by the addition of histidine to essential amino acid solutions given intravenously. Life Sci II. 1970 Jul 22;9(14):787–794. doi: 10.1016/0024-3205(70)90083-4. [DOI] [PubMed] [Google Scholar]
  4. Calloway D. H., Odell A. C., Margen S. Sweat and miscellaneous nitrogen losses in human balance studies. J Nutr. 1971 Jun;101(6):775–786. doi: 10.1093/jn/101.6.775. [DOI] [PubMed] [Google Scholar]
  5. Chan W., Wang M., Kopple J. D., Swendseid M. E. Citrulline levels and urea cycle enzymes in uremic rats. J Nutr. 1974 Jun;104(6):678–683. doi: 10.1093/jn/104.6.678. [DOI] [PubMed] [Google Scholar]
  6. Fisler J. L., Drenick E. J. Muscle biopsy needle for the percutaneous excision of large specimens. J Lab Clin Med. 1972 Apr;79(4):679–682. [PubMed] [Google Scholar]
  7. Fürst P. 15 N-studies in severe renal failure. II. Evidence for the essentiality of histidine. Scand J Clin Lab Invest. 1972 Nov;30(3):307–312. doi: 10.3109/00365517209084295. [DOI] [PubMed] [Google Scholar]
  8. Klein R. G., Halver J. E. Nutrition of salmonoid fishes: Arginine and histidine requirements of Chinook and coho salmon. J Nutr. 1970 Sep;100(9):1105–1109. doi: 10.1093/jn/100.9.1105. [DOI] [PubMed] [Google Scholar]
  9. Kofrányi E., Jekat F., Brand K., Hackenberg K., Hess B. Zur Bestimmung der biologischen Wertigkeit von Nahrungsproteinen. 13. Der Frage der Essentialität von Arginin und Histidin. Hoppe Seylers Z Physiol Chem. 1969 Nov;350(11):1401–1404. [PubMed] [Google Scholar]
  10. Kopple J. D., Coburn J. W. Metabolic studies of low protein diets in uremia. I. Nitrogen and potassium. Medicine (Baltimore) 1973 Nov;52(6):583–595. doi: 10.1097/00005792-197311000-00004. [DOI] [PubMed] [Google Scholar]
  11. NAKAGAWA I., TAKAHASHI T., SUZUKI T., KOBAYASHI K. Amino acid requirements of children: minimal needs of tryptophan, arginine and histidine based on nitrogen balance method. J Nutr. 1963 Jul;80:305–310. doi: 10.1093/jn/80.3.305. [DOI] [PubMed] [Google Scholar]
  12. NASSET E. S., GATEWOOD V. H. Nitrogen balance and hemoglobin of adult rats fed amino acid diets low in L- and D-histidine. J Nutr. 1954 Jun 10;53(2):163–176. doi: 10.1093/jn/53.2.163. [DOI] [PubMed] [Google Scholar]
  13. Pickford J. C., McGale E. H., Aber G. M. Studies on the metabolism of phenylalanine and tyrosine in patients with renal disease. Clin Chim Acta. 1973 Sep 28;48(1):77–83. doi: 10.1016/0009-8981(73)90219-2. [DOI] [PubMed] [Google Scholar]
  14. RODKEY F. L. DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ALBUMIN IN HUMAN SERUM. Clin Chem. 1965 Apr;11:478–487. [PubMed] [Google Scholar]
  15. ROSE W. C., HAINES W. J., WARNER D. T., JOHNSON J. E. The amino acid requirements of man. II. The role of threonine and histidine. J Biol Chem. 1951 Jan;188(1):49–58. [PubMed] [Google Scholar]
  16. ROSE W. C., HAINES W. J., WARNER D. T. The amino acid requirements of man. III. The rôle of isoleucine; additional evidence concerning histidine. J Biol Chem. 1951 Dec;193(2):605–612. [PubMed] [Google Scholar]
  17. ROSE W. C. The amino acid requirements of adult man. Nutr Abstr Rev. 1957 Jul;27(3):631–647. [PubMed] [Google Scholar]
  18. ROSE W. C., WIXOM R. L., LOCKHART H. B., LAMBERT G. F. The amino acid requirements of man. XV. The valine requirement; summary and final observations. J Biol Chem. 1955 Dec;217(2):987–995. [PubMed] [Google Scholar]
  19. SEBRELL W. H., Jr, McDANIEL E. G. Amino acids in the production of blood constituents in rats. J Nutr. 1952 Aug 11;47(4):477–486. doi: 10.1093/jn/47.4.477. [DOI] [PubMed] [Google Scholar]
  20. SNYDERMAN S. E., BOYER A., ROITMAN E., HOLT L. E., Jr, PROSE P. H. The histidine requirement of the infant. Pediatrics. 1963 May;31:786–801. [PubMed] [Google Scholar]
  21. SWENDSEID M. E., DUNN M. S. Amino acid requirements of young women based on nitrogen balance data. II. Studies on isoleucine and on minimum amounts of the eight essential amino acids fed simultaneously. J Nutr. 1956 Apr 10;58(4):507–517. doi: 10.1093/jn/58.4.507. [DOI] [PubMed] [Google Scholar]
  22. SWENDSEID M. E., WILLIAMS I., DUNN M. S. Amino acid requirements of young women based on nitrogen balance data. I. The sulfur-containing amino acids. J Nutr. 1956 Apr 10;58(4):495–505. doi: 10.1093/jn/58.4.495. [DOI] [PubMed] [Google Scholar]
  23. Weller L. A., Calloway D. H., Margen S. Nitrogen balance of men fed amino acid mixtures based on Rose's requirements, egg white protein, and serum free amino acid patterns. J Nutr. 1971 Nov;101(11):1499–1507. doi: 10.1093/jn/101.11.1499. [DOI] [PubMed] [Google Scholar]
  24. ZETTNER A., SELIGSON D. APPLICATION OF ATOMIC ABSORPTION SPECTROPHOTOMETRY IN THE DETERMINATION OF CALCIUM IN SERUM. Clin Chem. 1964 Oct;10:869–890. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

ACTIONS

RESOURCES

AltStyle によって変換されたページ (->オリジナル) /