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CHO1 CDP-diacylglycerol-serine O-phosphatidyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856748, updated on 5-Jul-2025

In addition, your package will include a detailed data report in both TSV and JSONL formats.

Official Symbol
CHO1
Official Full Name
CDP-diacylglycerol-serine O-phosphatidyltransferase
Primary source
SGD:S000000828
Locus tag
YER026C
See related
AllianceGenome:SGD:S000000828; FungiDB:YER026C; VEuPathDB:YER026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSS1
Summary
Enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity. Involved in phosphatidylserine biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CHO1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (207644..208474, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase. Letts VA, et al. Proc Natl Acad Sci U S A, 1983 Dec. PMID 6316353, Free PMC Article
  2. Identification of mitochondrial and microsomal phosphatidylserine synthase in Saccharomyces cerevisiae as the gene product of the CHO1 structural gene. Kohlwein SD, et al. J Bacteriol, 1988 Aug. PMID 2841305, Free PMC Article
  3. Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase. Kinney AJ, et al. Proc Natl Acad Sci U S A, 1988 Nov. PMID 2847149, Free PMC Article
  4. Primary structure and product characterization of the Saccharomyces cerevisiae CHO1 gene that encodes phosphatidylserine synthase. Kiyono K, et al. J Biochem, 1987 Nov. PMID 2830250
  5. Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER. Kannan M, et al. J Lipid Res, 2017 Mar. PMID 28119445, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, we found that Cho1p, like mammalian PS synthases is inhibited by its product, PS. This suggests a simple mechanism of activating Cho1p at membrane contact sites (MCSs); PS transport out of the ER at MCSs will stimulate Cho1p activity in these regions.
    Title: Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER.
  2. overexpression of CHO1 suppresses defects in the endocytic recycling pathway in flippase mutants. These results suggest that flippase-dependent vesicle formation is mediated by phospholipid flipping.
    Title: Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae.
  3. phosphatidylserine synthase is phosphorylated on Ser(46) and Ser(47) by protein kinase A, which results in a higher amount of enzyme for the net effect of stimulating the synthesis of phosphatidylserine
    Title: Phosphorylation of yeast phosphatidylserine synthase by protein kinase A: identification of Ser46 and Ser47 as major sites of phosphorylation.
  4. Respiratory deficiency mediates the regulation of CHO1 by mRNA stability in Saccharomyces cerevisiae.
    Title: Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae.
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
located_in organelle membrane IEA
Inferred from Electronic Annotation
more info
Preferred Names
CDP-diacylglycerol-serine O-phosphatidyltransferase
NP_010943.3
  • Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    207644..208474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178917.3 → NP_010943.3 TPA: CDP-diacylglycerol-serine O-phosphatidyltransferase

    See identical proteins and their annotated locations for NP_010943.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS5, P08456
    UniProtKB/TrEMBL
    A6ZQX5, B3LS39, C7GSH3, G2WCQ9, N1P5S6
    Conserved Domains (1) summary
    TIGR00473
    Location:87 → 242
    pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08456.3

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