Warning: The NCBI web site requires JavaScript to function. more...

U.S. flag

An official website of the United States government

Log in

Gene

Genes and mapped phenotypes

S I D E B A R
Format

Send to:

Choose Destination

DUR12 bifunctional urea carboxylase/allophanate hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852507, updated on 5-Jul-2025

In addition, your package will include a detailed data report in both TSV and JSONL formats.

Official Symbol
DUR12
Official Full Name
bifunctional urea carboxylase/allophanate hydrolase
Primary source
SGD:S000000412
Locus tag
YBR208C
See related
AllianceGenome:SGD:S000000412; FungiDB:YBR208C; VEuPathDB:YBR208C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DUR80
Summary
Enables allophanate hydrolase activity and urea carboxylase activity. Involved in urea catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in 3-methylcrotonyl-CoA carboxylase 1 deficiency; amino acid metabolic disorder; and propionic acidemia. Orthologous to human MCCC1 (methylcrotonyl-CoA carboxylase subunit 1) and PCCA (propionyl-CoA carboxylase subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See DUR12 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (636703..642210, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Constitutive expression of the DUR1,2 gene in an industrial yeast strain to minimize ethyl carbamate production during Chinese rice wine fermentation. Wu D, et al. FEMS Microbiol Lett, 2016 Jan. PMID 26538578
  2. cis-Dominant mutations which dramatically enhance DUR1,2 gene expression without affecting its normal regulation. Chisholm G, et al. Mol Cell Biol, 1984 May. PMID 6328278, Free PMC Article
  3. Ty insertions upstream and downstream of native DUR1,2 promoter elements generate different patterns of DUR1,2 expression in Saccharomyces cerevisiae. Chisholm GE, et al. J Bacteriol, 1992 Apr. PMID 1313414, Free PMC Article
  4. The urea amidolyase (DUR1,2) gene of Saccharomyces cerevisiae. Genbauffe FS, et al. DNA Seq, 1991. PMID 1802034
  5. Structural analysis of the dur loci in S. cerevisiae: two domains of a single multifunctional gene. Cooper TG, et al. Genetics, 1980 Mar. PMID 6105114, Free PMC Article

See all (53) citations in PubMed

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
enables allophanate hydrolase activity IEA
Inferred from Electronic Annotation
more info
enables allophanate hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
enables ligase activity IEA
Inferred from Electronic Annotation
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
enables urea carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables urea carboxylase activity IEA
Inferred from Electronic Annotation
more info
enables urea carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed
Process Evidence Code Pubs
involved_in allantoin catabolic process TAS
Traceable Author Statement
more info
PubMed
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
involved_in urea catabolic process IEA
Inferred from Electronic Annotation
more info
involved_in urea catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed
Preferred Names
bifunctional urea carboxylase/allophanate hydrolase
NP_009767.1
  • Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    636703..642210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178556.1 → NP_009767.1 TPA: bifunctional urea carboxylase/allophanate hydrolase

    See identical proteins and their annotated locations for NP_009767.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK5, P32528
    UniProtKB/TrEMBL
    C7GKH0, G2W9L2
    Conserved Domains (2) summary
    TIGR02712
    Location:633 → 1832
    urea_carbox; urea carboxylase
    TIGR02713
    Location:49 → 620
    allophanate_hyd; allophanate hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32528.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials

AltStyle によって変換されたページ (->オリジナル) /