Itgax MGI Mouse Gene Detail - MGI:96609 - integrin alpha X

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Itgax Gene Detail
Summary
  • Symbol
    Itgax
  • Name
    integrin alpha X
  • Synonyms
    Cd11c, CD11C (p150) alpha polypeptide, CR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96609
    NCBI Gene: 16411
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127728719-127749829 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    766 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0033072
protein coding gene Chr7:132534286-132556840 (+)
A/J MGP_AJ_G0033055
protein coding gene Chr7:128971104-128992074 (+)
AKR/J MGP_AKRJ_G0032987
protein coding gene Chr7:132331839-132354128 (+)
BALB/cJ MGP_BALBcJ_G0033056
protein coding gene Chr7:128634892-128655981 (+)
C3H/HeJ MGP_C3HHeJ_G0032770
protein coding gene Chr7:132224092-132252015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033566
protein coding gene Chr7:137695220-137723576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030538
protein coding gene Chr7:130154871-130180812 (+)
CAST/EiJ MGP_CASTEiJ_G0032099
protein coding gene Chr7:124012700-124040361 (+)
CBA/J MGP_CBAJ_G0032743
protein coding gene Chr7:142390585-142416227 (+)
DBA/2J MGP_DBA2J_G0032895
protein coding gene Chr7:126954708-126977304 (+)
FVB/NJ MGP_FVBNJ_G0032848
protein coding gene Chr7:126821412-126842562 (+)
LP/J MGP_LPJ_G0032989
protein coding gene Chr7:134006805-134030896 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032880
protein coding gene Chr7:143442129-143465452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033585
protein coding gene Chr7:131306805-131330050 (+)
PWK/PhJ MGP_PWKPhJ_G0031806
protein coding gene Chr7:119960797-119983253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031652
protein coding gene Chr7:118106312-118127928 (+)
WSB/EiJ MGP_WSBEiJ_G0032211
protein coding gene Chr7:132279083-132300580 (+)



Homology
more
  • Human Ortholog
    ITGAX, integrin subunit alpha X
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAX, integrin subunit alpha X
  • Synonyms
    CD11C, SLEB6
  • Links
    NCBI Gene ID: 3687
    neXtProt AC: NX_P20702
    UniProt: P20702

  • Chr Location
    16p11.2; chr16:31355134-31382999 (+) GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030789 Ensembl Gene Model | MGI Sequence Detail 21111 C57BL/6J ± kb
transcript ENSMUST00000033053 Ensembl | MGI Sequence Detail 4046 Not Applicable
polypeptide ENSMUSP00000033053 Ensembl | MGI Sequence Detail 1169 Not Applicable
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001013 integrin alpha-X
  • InterPro Domains
    IPR050525 Extracellular Matrix Assembly and Organization
    IPR013517 FG-GAP repeat
    IPR013519 Integrin alpha beta-propellor
    IPR000413 Integrin alpha chain
    IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    IPR013649 Integrin alpha, first immunoglubulin-like domain
    IPR028994 Integrin alpha, N-terminal
    IPR048285 Integrin alpha, second immunoglobulin-like domain
    IPR048633 Integrin alpha-X-like, third Ig-like domain
    IPR032695 Integrin domain superfamily
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q9QXH4 7 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11488, MGI:2141963
References
more
  • Summaries
    All 161
    Developmental Gene Expression 31
    Gene Ontology 17
    Phenotypes 30
  • Earliest
    J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
  • Latest
    J:362088 Tatsumi N, et al., CD301b(+) dendritic cell-derived IL-2 dictates CD4(+) T helper cell differentiation. Nat Commun. 2025 Feb 26;16(1):2002
TSS for Itgax:
(View these features in JBrowse)
Transcription Start Site Location Distance from Gene 5'-end
Tssr69379 Chr7:127728708-127728746 (+) 8 bp
Tssr69380 Chr7:127730662-127730686 (+) 1,955 bp
Tssr69381 Chr7:127732123-127732182 (+) 3,434 bp
Tssr69382 Chr7:127733922-127733948 (+) 5,216 bp
Tssr69383 Chr7:127733950-127733989 (+) 5,251 bp
Tssr69384 Chr7:127734013-127734024 (+) 5,300 bp
Tssr69385 Chr7:127734026-127734031 (+) 5,310 bp
Tssr69386 Chr7:127737562-127737586 (+) 8,855 bp
Tssr69387 Chr7:127738325-127738327 (+) 9,607 bp
Tssr69388 Chr7:127738431-127738442 (+) 9,718 bp
Tssr69389 Chr7:127739633-127739644 (+) 10,920 bp
Tssr69390 Chr7:127740379-127740391 (+) 11,666 bp
Tssr69391 Chr7:127741091-127741132 (+) 12,393 bp
Tssr69392 Chr7:127743779-127743798 (+) 15,070 bp
Tssr69393 Chr7:127743830-127743855 (+) 15,124 bp
Tssr69394 Chr7:127744014-127744029 (+) 15,303 bp
Tssr69395 Chr7:127745248-127745253 (+) 16,532 bp
Tssr69396 Chr7:127746591-127746640 (+) 17,897 bp
Tssr69397 Chr7:127747228-127747242 (+) 18,516 bp
Tssr69398 Chr7:127747665-127747682 (+) 18,955 bp
Tssr69399 Chr7:127748338-127748351 (+) 19,626 bp
Tssr69400 Chr7:127749351-127749375 (+) 20,644 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. last database update
12/17/2024
MGI 6.24 The Jackson Laboratory
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