Egf MGI Mouse Gene Detail - MGI:95290 - epidermal growth factor

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Egf Gene Detail
Summary
  • Symbol
    Egf
  • Name
    epidermal growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95290
    NCBI Gene: 13645
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129471223-129548971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.50 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2425 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0027871
protein coding gene Chr3:132340864-132423833 (-)
A/J MGP_AJ_G0027829
protein coding gene Chr3:127745912-127824237 (-)
AKR/J MGP_AKRJ_G0027794
protein coding gene Chr3:131054804-131132943 (-)
BALB/cJ MGP_BALBcJ_G0027842
protein coding gene Chr3:127586010-127664029 (-)
C3H/HeJ MGP_C3HHeJ_G0027571
protein coding gene Chr3:131447569-131527664 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028286
protein coding gene Chr3:137083095-137165997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025624
protein coding gene Chr3:123270021-123349436 (-)
CAST/EiJ MGP_CASTEiJ_G0027028
protein coding gene Chr3:131124153-131203503 (-)
CBA/J MGP_CBAJ_G0027547
protein coding gene Chr3:141697335-141781703 (-)
DBA/2J MGP_DBA2J_G0027688
protein coding gene Chr3:126937709-127016389 (-)
FVB/NJ MGP_FVBNJ_G0027655
protein coding gene Chr3:124519136-124600301 (-)
LP/J MGP_LPJ_G0027797
protein coding gene Chr3:133853600-133935853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027686
protein coding gene Chr3:149646827-149731557 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028343
protein coding gene Chr3:130723018-130807838 (-)
PWK/PhJ MGP_PWKPhJ_G0026752
protein coding gene Chr3:126668079-126802107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026577
protein coding gene Chr3:128786178-128868863 (-)
WSB/EiJ MGP_WSBEiJ_G0027107
protein coding gene Chr3:131435640-131519492 (-)



Homology
more
  • Human Ortholog
    EGF, epidermal growth factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGF, epidermal growth factor
  • Synonyms
    HOMG4, URG
  • Links
    NCBI Gene ID: 1950
    neXtProt AC: NX_P01133
    UniProt: P01133

  • Chr Location
    4q25; chr4:109912883-110013766 (+) GRCh38
Human Diseases
more
  • Diseases
    11 with human EGF associations

Human Disease Mouse Models
IDs
endometrial cancer

DOID:1380
DOID:5654
EFO:0004230
ICD10CM:C54.1
KEGG:05213
MESH:D016889
NCI:C27815
NCI:C3012
OMIM:608089
UMLS_CUI:C0007103
UMLS_CUI:C0014170
IDs
gallbladder cancer

DOID:3121
DOID:8090
DOID:8157
ICD10CM:C23
ICD9CM:156.0
MESH:D005706
NCI:C3048
NCI:C35676
NCI:C7481
UMLS_CUI:C0016978
UMLS_CUI:C0153452
UMLS_CUI:C0278806
IDs
glioblastoma

DOID:3068
DOID:3075
DOID:3080
MESH:D005909
NCI:C129295
NCI:C39750
NCI:C9094
UMLS_CUI:C0017636
UMLS_CUI:C0278878
UMLS_CUI:C1514422
IDs
hepatocellular carcinoma

DOID:684
DOID:5005
EFO:0000182
ICD10CM:C22.0
MESH:D006528
NCI:C3099
OMIM:114550
ORDO:88673
UMLS_CUI:C2239176
IDs
high grade glioma

DOID:3070
DOID:2627
KEGG:05214
MESH:D005910
NCI:C3059
NCI:C4822
OMIM:PS137800
ORDO:182067
UMLS_CUI:C0017638
UMLS_CUI:C0555198
IDs
lung adenocarcinoma

DOID:3910
DOID:4826
EFO:0000571
MESH:D000077192
NCI:C27745
NCI:C3512
UMLS_CUI:C0152013
UMLS_CUI:C1335060
IDs
lung non-small cell carcinoma
IDs
oligodendroglioma

DOID:3181
DOID:3182
MESH:D009837
NCI:C3288
UMLS_CUI:C0751396
IDs
primary hypomagnesemia
IDs
renal hypomagnesemia 4
IDs
Zollinger-Ellison syndrome

DOID:0050782
ICD10CM:E16.4
MESH:D015043
NCI:C3453
UMLS_CUI:C0043515
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    21 phenotype references
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13645 NCBI Gene Model | MGI Sequence Detail 77749 C57BL/6J ± kb
transcript NM_010113 RefSeq | MGI Sequence Detail 4773 ZRU/MplStud
polypeptide P01132 UniProt | EBI | MGI Sequence Detail 1217 Not Applicable
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    Genomic 3
    cDNA 143
    Primer pair 15
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9315, MGI:2139798
References
more
  • Summaries
    All 271
    Developmental Gene Expression 52
    Diseases 1
    Gene Ontology 39
    Phenotypes 21
  • Earliest
    J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
TSS for Egf:
(View these features in JBrowse)
Transcription Start Site Location Distance from Gene 5'-end
Tssr35627 Chr3:129548954-129548975 (-) 6 bp
Tssr35626 Chr3:129548903-129548914 (-) 62 bp
Tssr35625 Chr3:129548661-129548675 (-) 303 bp
Tssr35624 Chr3:129548598-129548604 (-) 370 bp
Tssr35623 Chr3:129548527-129548561 (-) 427 bp
Tssr35622 Chr3:129519938-129519941 (-) 29,031 bp
Tssr35621 Chr3:129518723-129518756 (-) 30,231 bp
Tssr35620 Chr3:129476934-129476973 (-) 72,017 bp
Tssr35619 Chr3:129472084-129472094 (-) 76,882 bp
Tssr35618 Chr3:129471648-129471655 (-) 77,319 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. last database update
12/17/2024
MGI 6.24 The Jackson Laboratory
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