Sik3 MGI Mouse Gene Detail - MGI:2446296 - SIK family kinase 3

Summary

• Symbol
  Sik3
• Name
  SIK family kinase 3
• Synonyms
  5730525O22Rik, 9030204A07Rik, mKIAA0999

• Feature Type
  protein coding gene
• IDs
  MGI:2446296
  NCBI Gene: 70661
• Alliance
  gene page
• Transcription Start Sites
  19 TSS

Location &
Maps

• Sequence Map
  Chr9:45924118-46135492 bp, + strand

  From Ensembl annotation of GRCm39
  
• View this region in JBrowse
  
• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 25.36 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  4930 from dbSNP Build 142
• Strain Annotations
  17

Homology

• Human Ortholog
  SIK3, SIK family kinase 3

• Vertebrate Orthologs
  3

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  147 phenotypes from 5 alleles in 5 genetic backgrounds
  2 phenotypes from multigenic genotypes
  32 phenotype references
  

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

• All Mutations and Alleles
  66
• Chemically induced (ENU)
  1
• Endonuclease-mediated
  9
• Gene trapped
  47
• Targeted
  9
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  72 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired chondrocyte hypertrophy during development, neonatal lethality and reduced size. Mice homozygous for a gain of function ENU mutation exhibit decreased total wake time, owing to an increase in inherent sleep need.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  46
• GO References
  7

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

• Blue cells = expressed in wild-type.
  Gray triangles = other expression annotations only
  (e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

• Assay Results
  714
• Tissues
  2
• cDNA Data
  71
• Literature Summary
  3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase sik3

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  4
• UniProt
  5
• CCDS
  CCDS23140.2

• Ensembl
  ENSMUSG00000034135 (Evidence)
• NCBI Gene
  70661

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000034135	Ensembl Gene Model | MGI Sequence Detail	211375	C57BL/6J	± kb
	transcript	ENSMUST00000126865	Ensembl | MGI Sequence Detail	6287	Not Applicable
	polypeptide	ENSMUSP00000121032	Ensembl | MGI Sequence Detail	1369	Not Applicable

For the selected sequence download in FASTA format forward to NCBI BLAST

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000013573 serine/threonine-protein kinase QSK
  (term hierarchy)
• EC
  2.7.11.1
• InterPro Domains
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR034672 Salt-Inducible kinase, catalytic domain
  IPR008271 Serine/threonine-protein kinase, active site
  IPR015940 Ubiquitin-associated domain
• GlyGen
  Q6P4S6 4 sites, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 71

  cDNA 71

  
  

  Microarray probesets 8

Other
Accession IDs

References

• Summaries
  All 69

  Developmental Gene Expression 3

  Gene Ontology 7

  Phenotypes 32
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:358879 Hayes ET, et al., SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response to Exogenous Gonadotropins In Vivo. Endocrinology. 2024 Aug 27;165(10)

TSS for Sik3:

(View these features in JBrowse)