Ppargc1a MGI Mouse Gene Detail - MGI:1342774 - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

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Ppargc1a Gene Detail
Summary
  • Symbol
    Ppargc1a
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  • Synonyms
    A830037N07Rik, Gm11133, Pgc1, Pgc-1alpha, Pgc-1alphaa, Pgco1, PPAR Gamma Coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342774
    NCBI Gene: 19017
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:51611592-51725068 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.02 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2574 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0029542
protein coding gene Chr5:50385447-50504929 (-)
A/J MGP_AJ_G0029510
protein coding gene Chr5:48612772-48729002 (-)
AKR/J MGP_AKRJ_G0029458
protein coding gene Chr5:50269993-50386804 (-)
BALB/cJ MGP_BALBcJ_G0029519
protein coding gene Chr5:49083021-49197664 (-)
C3H/HeJ MGP_C3HHeJ_G0029242
protein coding gene Chr5:50444384-50561568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029973
protein coding gene Chr5:52521630-52642764 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027213
protein coding gene Chr5:45413480-45520773 (-)
CAST/EiJ MGP_CASTEiJ_G0028650
protein coding gene Chr5:49414923-49538655 (-)
CBA/J MGP_CBAJ_G0029211
protein coding gene Chr5:54118438-54244511 (-)
DBA/2J MGP_DBA2J_G0029357
protein coding gene Chr5:48684330-48797559 (-)
FVB/NJ MGP_FVBNJ_G0029317
protein coding gene Chr5:48005860-48133211 (-)
LP/J MGP_LPJ_G0029442
protein coding gene Chr5:50852410-50969785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029345
protein coding gene Chr5:55223655-55367804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030006
protein coding gene Chr5:49771235-49890895 (-)
PWK/PhJ MGP_PWKPhJ_G0028374
protein coding gene Chr5:47734159-47850912 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028208
protein coding gene Chr5:49181255-49298961 (-)
WSB/EiJ MGP_WSBEiJ_G0028731
protein coding gene Chr5:49810410-49929958 (-)



Homology
more
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPARGC1A, PPARG coactivator 1 alpha
  • Synonyms
    LEM6, PGC1, PGC1A, PGC-1(alpha), PGC-1alpha, PGC-1v, PPARGC1
  • Links
    NCBI Gene ID: 10891
    neXtProt AC: NX_Q9UBK2
    UniProt: Q9UBK2

  • Chr Location
    4p15.2; chr4:23755041-24472905 (-) GRCh38
Human Diseases
more
  • Diseases
    4 with Ppargc1a mouse models; 8 with human PPARGC1A associations

Human Disease Mouse Models
IDs
Parkinson's disease

DOID:14330
ICD10CM:G20
ICD9CM:332
ICD9CM:332.0
KEGG:05012
MESH:D010300
NCI:C26845
OMIM:PS168600
ORDO:2828
UMLS_CUI:C0030567

 View 1 model
Mouse Models

Human Disease Modeled: Parkinson's disease

Allelic Composition Genetic Background Reference Phenotypes
Ppargc1atm1Dpk/Ppargc1atm1Dpk
B6.129X1-Ppargc1atm1Dpk/J J:298664 View
IDs
age related macular degeneration

DOID:10871
EFO:0001365
ICD10CM:H35.30
ICD9CM:362.50
MESH:D008268
NCI:C84391
OMIM:PS603075
UMLS_CUI:C0242383

 View 1 model
Mouse Models

Human Disease Modeled: age related macular degeneration

Allelic Composition Genetic Background Reference Phenotypes
Ppargc1atm1Brsp/Ppargc1a+
 involves: 129S4/SvJae * C57BL/6 J:264271 View
IDs
cardiomyopathy

DOID:0050700
ICD10CM:I42
ICD9CM:425
ICD9CM:425.9
MESH:D009202
NCI:C34830
NCI:C53654
UMLS_CUI:C0033141
UMLS_CUI:C0036529
UMLS_CUI:C0878544

 View 1 model
Mouse Models

Human Disease Modeled: cardiomyopathy

Allelic Composition Genetic Background Reference Phenotypes
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
 involves: FVB/N * FVB/NTac J:96614 View
IDs
congestive heart failure

DOID:6000
DOID:395
ICD10CM:I50
ICD10CM:I50.9
ICD9CM:428
ICD9CM:428.0
ICD9CM:428.9
MESH:D006333
NCI:C3080
NCI:C50577
UMLS_CUI:C0018801
UMLS_CUI:C0018802

 View 1 model
Mouse Models

Human Disease Modeled: congestive heart failure

Allelic Composition Genetic Background Reference Phenotypes
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
 involves: FVB/N * FVB/NTac J:96614 View
IDs
amyotrophic lateral sclerosis

DOID:332
ICD10CM:G12.21
ICD9CM:335.20
KEGG:05014
MESH:D000690
NCI:C34373
OMIM:PS105400
ORDO:803
UMLS_CUI:C0002736
IDs
cardiovascular system disease

DOID:1287
DOID:73
ICD9CM:429.2
MESH:D002318
NCI:C2931
UMLS_CUI:C0007222
IDs
Huntington's disease

DOID:12858
ICD10CM:G10
ICD9CM_2006:333.4
ICD9CM:333.4
KEGG:05016
MESH:D006816
NCI:C82342
OMIM:143100
UMLS_CUI:C0020179
IDs
macular degeneration
IDs
malignant fibrous histiocytoma

DOID:1907
MESH:D051677
NCI:C4247
UMLS_CUI:C0334463
IDs
metabolic dysfunction-associated steatotic liver disease
IDs
type 2 diabetes mellitus
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    142 phenotypes from 11 alleles in 19 genetic backgrounds
    30 phenotypes from multigenic genotypes
    3 images
    281 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial postnatal lethality, abnormal glucose and insulin homeostasis, resistance to diet induced obesity, increased oxygen consumption, spongiform encephalopathy, hyperactivity, increased startle reflex, and limb grasping.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029167 Ensembl Gene Model | MGI Sequence Detail 113477 C57BL/6J ± kb
    transcript ENSMUST00000132734 Ensembl | MGI Sequence Detail 6464 Not Applicable
    polypeptide ENSMUSP00000117040 Ensembl | MGI Sequence Detail 797 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 46
      Primer pair 17
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1203734, MGI:2443650, MGI:3779388
    References
    more
    • Summaries
      All 628
      Developmental Gene Expression 101
      Diseases 3
      Gene Ontology 36
      Phenotypes 281
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:363192 Dumesic PA, et al., RBM43 controls PGC1alpha translation and a PGC1alpha-STING signaling axis. Cell Metab. 2025 Mar 4;37(3):742-757.e8
    TSS for Ppargc1a:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr50973 Chr5:51725059-51725074 (-) 1 bp
    Tssr50972 Chr5:51724485-51724490 (-) 580 bp
    Tssr50971 Chr5:51711238-51711247 (-) 13,825 bp
    Tssr50970 Chr5:51711204-51711230 (-) 13,851 bp
    Tssr50969 Chr5:51704911-51704915 (-) 20,155 bp
    Tssr50968 Chr5:51691868-51691871 (-) 33,198 bp
    Tssr50967 Chr5:51683652-51683656 (-) 41,414 bp
    Tssr50966 Chr5:51654647-51654653 (-) 70,418 bp
    Tssr50965 Chr5:51653140-51653151 (-) 71,922 bp
    Tssr50964 Chr5:51653068-51653083 (-) 71,992 bp
    Tssr50963 Chr5:51636622-51636646 (-) 88,434 bp
    Tssr50962 Chr5:51615459-51615477 (-) 109,600 bp
    Tssr50961 Chr5:51615417-51615442 (-) 109,638 bp
    Tssr50960 Chr5:51615087-51615099 (-) 109,975 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    12/17/2024
    MGI 6.24 The Jackson Laboratory
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