Stx1a MGI Mouse Gene Detail - MGI:109355 - syntaxin 1A (brain)

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Stx1a Gene Detail
Summary
  • Symbol
    Stx1a
  • Name
    syntaxin 1A (brain)
  • Synonyms
    HPC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109355
    NCBI Gene: 20907
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135052336-135079954 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    870 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0030170
protein coding gene Chr5:139502726-139548238 (+)
A/J MGP_AJ_G0030138
protein coding gene Chr5:133547564-133575409 (+)
AKR/J MGP_AKRJ_G0030071
protein coding gene Chr5:137890044-137918888 (+)
BALB/cJ MGP_BALBcJ_G0030148
protein coding gene Chr5:134905593-134933253 (+)
C3H/HeJ MGP_C3HHeJ_G0029864
protein coding gene Chr5:138450698-138480219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030601
protein coding gene Chr5:144737572-144771833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027824
protein coding gene Chr5:127846196-127873781 (+)
CAST/EiJ MGP_CASTEiJ_G0029273
protein coding gene Chr5:137875083-137901314 (+)
CBA/J MGP_CBAJ_G0029834
protein coding gene Chr5:150395517-150435923 (+)
DBA/2J MGP_DBA2J_G0029985
protein coding gene Chr5:133444237-133478816 (+)
FVB/NJ MGP_FVBNJ_G0029940
protein coding gene Chr5:132582810-132612415 (+)
LP/J MGP_LPJ_G0030073
protein coding gene Chr5:139962176-139992948 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029972
protein coding gene Chr5:153410099-153454382 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030641
protein coding gene Chr5:137633804-137662861 (+)
PWK/PhJ MGP_PWKPhJ_G0028988
protein coding gene Chr5:132492400-132519925 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028823
protein coding gene Chr5:135195738-135225012 (+)
WSB/EiJ MGP_WSBEiJ_G0029347
protein coding gene Chr5:138386400-138414266 (+)



Homology
more
  • Human Ortholog
    STX1A, syntaxin 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STX1A, syntaxin 1A
  • Synonyms
    HPC-1, P35-1, STX1, SYN1A
  • Links
    NCBI Gene ID: 6804
    neXtProt AC: NX_Q16623
    UniProt: Q16623

  • Chr Location
    7q11.23; chr7:73699206-73719672 (-) GRCh38
Human Diseases
more
  • Diseases
    1 with Stx1a mouse models; 2 with human STX1A associations

Human Disease Mouse Models
IDs
disease of mental health

DOID:150
ICD10CM:F99
MESH:D001523
NCI:C2893
UMLS_CUI:C0004936

 View 2 models
Mouse Models

Human Disease Modeled: disease of mental health

Allelic Composition Genetic Background Reference Phenotypes
Stx1atm1Tfuj/Stx1atm1Tfuj
B6.Cg-Stx1atm1Tfuj J:171786 View
Stx1atm1Tfuj/Stx1a+
 B6.Cg-Stx1atm1Tfuj J:171786 View
IDs
Creutzfeldt-Jakob disease

DOID:11949
EFO:0004226
ICD10CM:A81.0
ICD9CM:046.1
ICD9CM_2006:046.1
MESH:D007562
NCI:C26802
OMIM:123400
UMLS_CUI:C0022336
IDs
Hirschsprung's disease
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for one targeted mutation display impairments in LTP, cued fear memory consolidation and cued fear memory extinction while mice with another targeted mutation show no behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007207 Ensembl Gene Model | MGI Sequence Detail 27619 C57BL/6J ± kb
    transcript ENSMUST00000005509 Ensembl | MGI Sequence Detail 2162 Not Applicable
    polypeptide ENSMUSP00000005509 Ensembl | MGI Sequence Detail 288 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 4
      cDNA 43
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38400
    References
    more
    • Summaries
      All 215
      Developmental Gene Expression 92
      Diseases 3
      Gene Ontology 38
      Phenotypes 48
    • Earliest
      J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
    • Latest
      J:347617 Nakayama T, et al., Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model. Cell Rep. 2024 Apr 23;43(4):114101
    TSS for Stx1a:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr49129 Chr5:135052360-135052361 (+) 25 bp
    Tssr49130 Chr5:135052375-135052434 (+) 69 bp
    Tssr49131 Chr5:135069979-135070019 (+) 17,663 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    12/17/2024
    MGI 6.24 The Jackson Laboratory
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