Il6ra MGI Mouse Gene Detail - MGI:105304 - interleukin 6 receptor, alpha

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Il6ra Gene Detail
Summary
  • Symbol
    Il6ra
  • Name
    interleukin 6 receptor, alpha
  • Synonyms
    CD126, Il6r, IL-6R, IL-6 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105304
    NCBI Gene: 16194
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89776631-89820503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1082 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0027448
protein coding gene Chr3:90102973-90162879 (-)
A/J MGP_AJ_G0027412
protein coding gene Chr3:87120499-87174059 (-)
AKR/J MGP_AKRJ_G0027376
protein coding gene Chr3:89246005-89305782 (-)
BALB/cJ MGP_BALBcJ_G0027421
protein coding gene Chr3:87091730-87141287 (-)
C3H/HeJ MGP_C3HHeJ_G0027163
protein coding gene Chr3:89429874-89484645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027867
protein coding gene Chr3:93491149-93550694 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025219
protein coding gene Chr3:82610344-82661400 (-)
CAST/EiJ MGP_CASTEiJ_G0026609
protein coding gene Chr3:89807975-89860874 (-)
CBA/J MGP_CBAJ_G0027137
protein coding gene Chr3:96722714-96784193 (-)
DBA/2J MGP_DBA2J_G0027275
protein coding gene Chr3:86499290-86549162 (-)
FVB/NJ MGP_FVBNJ_G0027243
protein coding gene Chr3:84835143-84884863 (-)
LP/J MGP_LPJ_G0027384
protein coding gene Chr3:91179659-91235697 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027263
protein coding gene Chr3:102905502-102971359 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027926
protein coding gene Chr3:88987863-89045292 (-)
PWK/PhJ MGP_PWKPhJ_G0026343
protein coding gene Chr3:86386656-86439806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026162
protein coding gene Chr3:88174991-88227237 (-)
WSB/EiJ MGP_WSBEiJ_G0026691
protein coding gene Chr3:89389342-89445402 (-)



Homology
more
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL6R, interleukin 6 receptor
  • Synonyms
    CD126, gp80, HIES5, IL-1Ra, IL6Q, IL6QTL, IL-6R, IL-6R-1, IL-6RA, IL6RA, IL6RQ
  • Links
    NCBI Gene ID: 3570
    neXtProt AC: NX_P08887
    UniProt: P08887

  • Chr Location
    1q21.3; chr1:154405193-154469450 (+) GRCh38
Human Diseases
more
  • Diseases
    5 with human IL6R associations

Human Disease Mouse Models
IDs
Alzheimer's disease

DOID:10652
ICD10CM:G30
ICD9CM:331.0
KEGG:05010
MESH:D000544
NCI:C2866
UMLS_CUI:C0002395
IDs
Huntington's disease

DOID:12858
ICD10CM:G10
ICD9CM_2006:333.4
ICD9CM:333.4
KEGG:05016
MESH:D006816
NCI:C82342
OMIM:143100
UMLS_CUI:C0020179
IDs
hyper IgE syndrome
IDs
obesity

DOID:9970
EFO:0001073
ICD10CM:E66.9
ICD9CM:278.00
MESH:D009765
NCI:C159658
OMIM:601665
UMLS_CUI:C0028754
IDs
stomach cancer

DOID:10534
DOID:10539
DOID:10542
DOID:10543
DOID:4713
ICD10CM:C16
ICD10CM:C16.2
ICD10CM:C16.5
ICD10CM:C16.6
ICD9CM:151
ICD9CM:151.4
ICD9CM:151.5
ICD9CM:151.6
ICD9CM:151.9
MESH:D013274
NCI:C3387
NCI:C9331
OMIM:613659
UMLS_CUI:C0024623
UMLS_CUI:C0038356
UMLS_CUI:C0153421
UMLS_CUI:C0153422
UMLS_CUI:C0153423
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 8 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective T helper 17 cells development. Mice homozygous for a different knock-out allele exhibit abnormaly inflammatory response and abnormal wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16194 NCBI Gene Model | MGI Sequence Detail 43873 C57BL/6J ± kb
    transcript NM_010559 RefSeq | MGI Sequence Detail 3377 ZRU/MplStud
    polypeptide P22272 UniProt | EBI | MGI Sequence Detail 460 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 18
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11392, MGD-MRK-32345
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 18
      Diseases 2
      Gene Ontology 8
      Phenotypes 101
    • Earliest
      J:43406 Sugita T, et al., Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J Exp Med. 1990 Jun 1;171(6):2001-9
    • Latest
      J:354960 Chang Y, et al., TGF-beta specifies T(FH) versus T(H)17 cell fates in murine CD4(+) T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818
    TSS for Il6ra:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr34167 Chr3:89820493-89820509 (-) 2 bp
    Tssr34166 Chr3:89820451-89820479 (-) 38 bp
    Tssr34165 Chr3:89820409-89820418 (-) 89 bp
    Tssr34164 Chr3:89811814-89811825 (-) 8,683 bp
    Tssr34163 Chr3:89811723-89811734 (-) 8,774 bp
    Tssr34162 Chr3:89811702-89811717 (-) 8,793 bp
    Tssr34161 Chr3:89811680-89811689 (-) 8,818 bp
    Tssr34160 Chr3:89798773-89798785 (-) 21,724 bp
    Tssr34159 Chr3:89779052-89779059 (-) 41,447 bp
    Tssr34158 Chr3:89778360-89778374 (-) 42,136 bp
    Tssr34157 Chr3:89777535-89777551 (-) 42,960 bp
    Tssr34156 Chr3:89777524-89777533 (-) 42,974 bp
    Tssr34155 Chr3:89777508-89777518 (-) 42,990 bp
    Tssr34154 Chr3:89777484-89777501 (-) 43,010 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    12/17/2024
    MGI 6.24 The Jackson Laboratory
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