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Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1. Cai H, Lin X et al. Science. 2025 Nov 20;390(6775):eadt8794.
High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223. Hou CD, Bellis N et al. J Mol Biol. 2025 Nov 1;437(21):169386.
How augmin establishes the angle of the microtubule branch site. Travis SM, Kraus J et al. Nat Commun. 2025 Oct 31;16(1):9646.
Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding. Jing T, Shan Z et al. Nat Commun. 2025 Oct 24;16(1):9430.
Crystal structures of agonist-bound human cannabinoid receptor CB1. Hua T, Vemuri K et al. Nature. 2025 Oct 16;646(8085):754–758.
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).
December 25, 2024
The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
The PDB/UniProt Info tool retrieves sequence and structure annotations for Protein Data Bank (PDB) entries using a Web service provided by the RCSB PDB. Sequences are displayed in Multalign Viewer, and feature annotations from UniProt are mapped onto the sequences as regions or colored boxes. In the region browser (figure at right):
Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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