C. albicans PFK2/C7_01800C Summary

Last curated 2025年11月05日
See the Literature Guide for most recent publications.

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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
PFK2 BASIC INFORMATION [ View References ]
Standard Name PFK21
Systematic Name, Reference Strain C7_01800C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.6540
Alias orf19.13893, IPF20535.12 , IPF10598.12 , Contig4-2763_00053 , orf6.52744 , CA31122 , CaJ7.02075 , CaO19_65406 , CaJ7_02076 , CaO19.65406 , CaO19.138936 , orf19.6540, C7_01800C_B, C7_01800C
Feature Type ORF, Verified
Description Phosphofructokinase beta subunit; forms a heterooctamer with Pfk1; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced (1, 7, 8, 9, 10, 11, 12, 13, 14)
Literature
Name Description PhosphoFructoKinase
Allele Name C7_01800C_B
Allelic Variation No allelic variation in feature
CUG Codons C7_01800C_A: 1
C7_01800C_B: 1
Systematic Names Used in Other Strains CAWG_05531 (C. albicans WO-1)
Orthologous genes in Candida species C. dubliniensis CD36 Ortholog(s) : Cd36_71630
C. parapsilosis CDC317 Ortholog(s) : CPAR2_703030
C. auris B8441 Ortholog(s) : B9J08_004928
C. glabrata CBS138 Ortholog(s) : CAGL0L10758g/PFK2
View ortholog cluster : 19 genes among 19 Candida-related species/strains
Ortholog(s) in non-CGD species N. crassa (emp-3) ; S. pombe (SPBC16H5.02) ; S. cerevisiae (PFK2)
Best hit(s) in non-CGD species A. nidulans (pfkA)
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GO Annotations View all PFK2 GO evidence and references

Molecular Function
Manually curated * 6-phosphofructokinase activity (IGI with S. cerevisiae: PFK1, S. cerevisiae: PFK2, IDA)
Computational * ATP binding (IEA with S. pombe: SPBC16H5.02)
* fructose-6-phosphate binding (IEA with S. pombe: SPBC16H5.02)

Biological Process
Manually curated * fructose 1,6-bisphosphate metabolic process (IDA)
* fructose 6-phosphate metabolic process (IDA)
* glycolytic process (IGI with S. cerevisiae: PFK1, S. cerevisiae: PFK2)
Computational * fructose 1,6-bisphosphate metabolic process (IEA with S. pombe: SPBC16H5.02)
* fructose 6-phosphate metabolic process (IEA with S. pombe: SPBC16H5.02)

Cellular Component
Manually curated * 6-phosphofructokinase complex (IGI with S. cerevisiae: PFK1, IDA)
Pathways * Glycolysis
* Sorbitol Degradation
Mutant Phenotype View all PFK2 Phenotype details and references
Large-scale survey
null * viable

Sequence Information Ca22chr7A_C_albicans_SC5314:388798 to 385958 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to2841388,798to385,9582016年01月21日2014年06月24日

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Maps & Displays
Sequence Information Ca22chr7A_C_albicans_SC5314:388798 to 385958 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C7_01800C_B 		Ca22chr7B_C_albicans_SC5314:388801 to 385961 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to2841388,801to385,9612016年01月21日2014年06月24日

Allele Location
Allele C7_01800C_B Ca22chr7B_C_albicans_SC5314:388801 to 385961 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links BioGRID | CGOB | Entrez Gene (1, 2, 3) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5, 6, 7, 8) | Non-periodic Expression | Pedant | PhylomeDB | TrEMBL | Transcription Modules
Primary CGDID CAL0000190617
ADDITIONAL INFORMATION for PFK2
Gene/Sequence Resources
LOCUS SUMMARY NOTES for PFK2 (Last Updated: 2011年06月16日)
  • PFK2 encodes a phosphofructokinase beta subunit which functions as a Pfk1p-Pfk2p heteromultimer (1)
  • specific Pfk activity of C. albicans decreases twofold upon induction of hyphal growth (1)
  • it is a stationary-phase enriched protein (10)
  • heterologous expression of PFK1 or PFK2 in S. cerevisiae is able to complement the glucose-negative phenotype of a S. cerevisiae pfk1 pfk2 double mutant (1)
  • its expression is induced during growth in a biofilm (12)
  • the transcript is also induced by exposure to fluconazole (9)
  • expression is downregulated during phagocytosis by J774 macrophages (8)
  • expression is repressed by co-incubation with whole human blood or with a human PMN fraction (15)
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PFK2]
1) Lorberg A, et al. (1999) Genetic and biochemical characterization of phosphofructokinase from the opportunistic pathogenic yeast Candida albicans. Eur J Biochem 260(1):217-26
CGD Papers Entry Pubmed Entry Reference LINKOUT
2) CandidaDB
CGD Papers Entry
3) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
4) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry
5) Chibana H, et al. (2005) Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics 170(4):1525-37
CGD Papers Entry Pubmed Entry Reference LINKOUT
6) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
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7) Harcus D, et al. (2004) Transcription profiling of cyclic AMP signaling in Candida albicans. Mol Biol Cell 15(10):4490-9
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8) Lorenz MC, et al. (2004) Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell 3(5):1076-87
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9) Copping VM, et al. (2005) Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. J Antimicrob Chemother 55(5):645-54
CGD Papers Entry Pubmed Entry Reference LINKOUT
10) Kusch H, et al. (2008) A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases. Int J Med Microbiol 298(3-4):291-318
CGD Papers Entry Pubmed Entry Reference LINKOUT
11) Nett JE, et al. (2009) Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis 200(2):307-13
CGD Papers Entry Pubmed Entry Reference LINKOUT Web Supplement
12) Bonhomme J, et al. (2011) Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans. Mol Microbiol 80(4):995-1013
CGD Papers Entry Pubmed Entry Reference LINKOUT Data
13) Nobile CJ, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148(1-2):126-38
CGD Papers Entry Pubmed Entry Reference LINKOUT Data
14) Luo J, et al. (2025) Preliminary study of the lethal fungus Candida albicans phosphofructokinase-1 as a potential therapeutic target. Int J Biol Macromol :148039
CGD Papers Entry Pubmed Entry
15) Fradin C, et al. (2005) Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 56(2):397-415
CGD Papers Entry Pubmed Entry Reference LINKOUT Web Supplement Data

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