C. albicans RHD3/C4_04050C Summary

Last curated 2021年10月26日
See the Literature Guide for most recent publications.

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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
RHD3 BASIC INFORMATION [ View References ]
Standard Name RHD31
Systematic Name, Reference Strain C4_04050C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.5305
Alias PGA292 , LDG73
orf19.12765, orf6.82942 , IPF21875.12 , IPF8527.12 , Contig4-2961_00094 , CA54762 , CaO19.127655 , CaO19.53055 , IPF85272 , orf19.5305, C4_04050C_B, C4_04050C
Feature Type ORF, Verified
Description GPI-anchored yeast-associated cell wall protein; induced in high iron; clade-associated gene expression; not essential for cell wall integrity; fluconazole-repressed; flow model and Spider biofilm repressed (1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
Literature
Name Description Repressed during Hyphae Development1, 6
Allele Name C4_04050C_B
Allelic Variation No allelic variation in feature
CUG Codons C4_04050C_A: 1
C4_04050C_B: 1
Systematic Names Used in Other Strains CAWG_03394 (C. albicans WO-1)
Orthologous genes in Candida species C. dubliniensis CD36 Ortholog(s) : Cd36_43810/RHD3
C. parapsilosis CDC317 Ortholog(s) : CPAR2_402010/RHD3
View ortholog cluster : 7 genes among 7 Candida-related species/strains
Best hits in Candida species C. auris B8441 best hit(s) : B9J08_004476
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GO Annotations View all RHD3 GO evidence and references

Molecular Function
Manually curated * molecular_function unknown (ND)

Biological Process
Manually curated * biological process involved in interspecies interaction between organisms (IMP)
* fungal-type cell wall organization (IMP)

Cellular Component
Manually curated * cell surface (IDA)
* extracellular region (IDA)
* fungal-type cell wall (IDA)
* hyphal cell wall (IDA)
* membrane (ISS)
* yeast-form cell wall (IDA)
High-throughput * cell surface (ISS)
* extracellular region (IDA)
* plasma membrane (IDA)
* yeast-form cell wall (IDA)
Mutant Phenotype View all RHD3 Phenotype details and references
Classical genetics
homozygous null * cell wall morphology: abnormal
* induction of host response: decreased
* viable
* virulence: decreased

Large-scale survey
null * viable

repressible * vegetative growth: normal rate
* viable

Sequence Information Ca22chr4A_C_albicans_SC5314:868295 to 867681 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to615868,295to867,6812016年01月21日2014年06月24日

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Sequence Analysis Tools
Maps & Displays
Sequence Information Ca22chr4A_C_albicans_SC5314:868295 to 867681 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C4_04050C_B 		Ca22chr4B_C_albicans_SC5314:868320 to 867706 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to615868,320to867,7062016年01月21日2014年06月24日

Allele Location
Allele C4_04050C_B Ca22chr4B_C_albicans_SC5314:868320 to 867706 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links CGOB | Entrez Gene (1, 2) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5, 6) | Non-periodic Expression | Pedant | PhylomeDB | SwissProt | TrEMBL
Primary CGDID CAL0000190005
ADDITIONAL INFORMATION for RHD3
Gene/Sequence Resources
LOCUS SUMMARY NOTES for RHD3 (Last Updated: 2011年05月14日)
  • RHD3 encodes a putative glycosylphosphatidylinositol (GPI)-anchored cell wall protein; it is covalently linked to the beta-1,3-glucan framework of the cell wall via beta-1,6-glucan (, 13)
  • it is a small and abundant O-glycosylated protein that requires the protein-O-mannosyl transferase Pmt1p for glycosylation (13)
  • RHD3 was named for Repressed during Hyphae Development; its transcription is strongly expressed in yeast cells but decreased upon the yeast-hyphal switch (1, 13)
  • it is also called PGA29 and LDG7 in the scientific literature
  • Rhd3p is much more abundant in cell wall at pH 4 suggesting regulation by pH (17)
  • rhd3 mutants display a significant reduction of cell wall mannan however, Rhd3p does not appear to play a role in cell wall integrity 20533408 mutants form normal hyphae (13)
  • the rhd3 mutant shows decreased virulence in a reconstituted human epithelium infection model; the mutants induces less proinflammatory cytokines, such as GM-CSF, TNF, IL-6 and IL-8 (13)
  • it is transcriptionally regulated by iron; expression levels are greater in high iron (7)
  • its transcript is induced during cell wall regeneration following protoplasting (18)
  • RHD3 displays clade-associated gene expression (10)
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RHD3]
1) Nantel A, et al. (2002) Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition. Mol Biol Cell 13(10):3452-65
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2) CandidaDB
CGD Papers Entry
3) Angiolella L, et al. (2009) Localisation of Bgl2p upon antifungal drug treatment in Candida albicans. Int J Antimicrob Agents 33(2):143-8
CGD Papers Entry Pubmed Entry Reference LINKOUT
4) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
5) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
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6) De Groot PW, et al. (2003) Genome-wide identification of fungal GPI proteins. Yeast 20(9):781-96
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7) Lan CY, et al. (2004) Regulatory networks affected by iron availability in Candida albicans. Mol Microbiol 53(5):1451-69
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8) Harcus D, et al. (2004) Transcription profiling of cyclic AMP signaling in Candida albicans. Mol Biol Cell 15(10):4490-9
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9) Castillo L, et al. (2008) A study of the Candida albicans cell wall proteome. Proteomics 8(18):3871-81
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10) MacCallum DM, et al. (2009) Property differences among the four major Candida albicans strain clades. Eukaryot Cell 8(3):373-87
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11) Cabezon V, et al. (2009) Analysis of Candida albicans plasma membrane proteome. Proteomics 9(20):4770-86
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12) Mitchell AP (2009) Possibly essential genes; no disruptants obtained by UAU1 method using the BWP17 strain
CGD Papers Entry
13) de Boer AD, et al. (2010) The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence. Yeast 27(8):611-24
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14) Heilmann CJ, et al. (2011) Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile. Microbiology 157(Pt 8):2297-2307
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15) Sorgo AG, et al. (2011) Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell 10(8):1071-81
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16) Nobile CJ, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148(1-2):126-38
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17) Sosinska GJ, et al. (2011) Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology 157(Pt 1):136-46
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18) Castillo L, et al. (2006) Genomic response programs of Candida albicans following protoplasting and regeneration. Fungal Genet Biol 43(2):124-34
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