C. albicans DCK1/C2_04050C Summary

Last curated 2025年05月29日
See the Literature Guide for most recent publications.

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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
DCK1 BASIC INFORMATION [ View References ]
Standard Name DCK11
Systematic Name, Reference Strain C2_04050C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.815
Alias orf19.8435, IPF5806.22 , IPF29663.12 , Contig4-2714_00023 , Contig4-2714_00033 , orf6.454 , orf6.67064 , YLR422W, CA42162 , CaO19.84355 , CaO19.8155 , IPF58062 , orf19.815, C2_04050C_B, C2_04050C
Feature Type ORF, Verified
Description Putative guanine nucleotide exchange factor; required for embedded filamentous growth; activates Rac1; has a DOCKER domain; similar to adjacent DCK2 and to S. cerevisiae Ylr422wp; regulated by Nrg1; Spider biofilm induced (1, 6, 7, 8)
Literature
Name Description DoCKer domain1
Allele Name C2_04050C_B
Allelic Variation Synonymous variation between alleles
CUG Codons C2_04050C_A: 2
C2_04050C_B: 2
Systematic Names Used in Other Strains CAWG_04163 (C. albicans WO-1)
Orthologous genes in Candida species C. auris B8441 Ortholog(s) : B9J08_003624
C. dubliniensis CD36 Ortholog(s) : Cd36_18700
C. parapsilosis CDC317 Ortholog(s) : CPAR2_209310
C. glabrata CBS138 Ortholog(s) : CAGL0J04642g
View ortholog cluster : 19 genes among 19 Candida-related species/strains
Ortholog(s) in non-CGD species S. cerevisiae (DCK1)
Best hit(s) in non-CGD species A. nidulans (AN0463) ; N. crassa (NCU09492)
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JBrowse for feature C2_04050C_A

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GO Annotations View all DCK1 GO evidence and references

Molecular Function
Computational * guanyl-nucleotide exchange factor activity (IEA with EBI: Dedicator of cytokinesis)

Biological Process
Manually curated * cellular response to biotic stimulus (IMP)
* cellular response to starvation (IMP)
* filamentous growth (IMP, IGI with C. albicans: RAC1)
* filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* filamentous growth of a population of unicellular organisms in response to starvation (IMP)
* fungal-type cell wall organization (IMP)
Computational * small GTPase-mediated signal transduction (IEA with EBI: Dedicator of cytokinesis)

Cellular Component
Manually curated * membrane (IDA)
Mutant Phenotype View all DCK1 Phenotype details and references
Classical genetics
heterozygous null * filamentous growth: decreased
* viable

homozygous null * invasive growth: absent
* phenotypic switching: abnormal
* resistance to Calcofluor White: decreased
* resistance to Congo Red: decreased
* viable

Large-scale survey
heterozygous null * cell size: increased

homozygous null * colony appearance: abnormal
* competitive fitness: normal
* vegetative growth: normal rate
* viable

null * viable

Sequence Information Ca22chr2A_C_albicans_SC5314:853277 to 847533 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to5745853,277to847,5332016年01月21日2014年06月24日

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays
Sequence Information Ca22chr2A_C_albicans_SC5314:853277 to 847533 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C2_04050C_B 		Ca22chr2B_C_albicans_SC5314:853311 to 847567 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to5745853,311to847,5672016年01月21日2014年06月24日

Allele Location
Allele C2_04050C_B Ca22chr2B_C_albicans_SC5314:853311 to 847567 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links CGOB | Entrez Gene (1, 2) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5, 6) | Non-periodic Expression | Pedant | PhylomeDB | TrEMBL | Transcription Modules
Primary CGDID CAL0000181698
ADDITIONAL INFORMATION for DCK1
Gene/Sequence Resources
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCK1]
1) Hope H, et al. (2008) Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans. Mol Biol Cell 19(9):3638-51
CGD Papers Entry Pubmed Entry Reference LINKOUT
2) CandidaDB
CGD Papers Entry
3) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
4) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry
5) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT
6) Murad AM, et al. (2001) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20(17):4742-52
CGD Papers Entry Pubmed Entry Reference LINKOUT
7) Uhl MA, et al. (2003) Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans. EMBO J 22(11):2668-78
CGD Papers Entry Pubmed Entry Reference LINKOUT Web Supplement
8) Nobile CJ, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148(1-2):126-38
CGD Papers Entry Pubmed Entry Reference LINKOUT Data

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