Description:
The WW-binding motif for Dystrophin (DMD) and the SH3-binding motif for Growth factor receptor-bound protein 2 (GRB2) on Dystroglycan (DAG1) overlap, making their interactions mutually exclusive and competitive.
Participants:
(1) Dystroglycan (DAG1)
(2) Dystrophin (DMD)
(3) Growth factor receptor-bound protein 2 (GRB2)
(1) Characterization of the beta-dystroglycan-growth factor receptor 2 (Grb2) interaction.
Russo et al. Biochem. Biophys. Res. Commun. (2000)
(2) Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Huang et al. Nat. Struct. Biol. (2000)
(3) Dystroglycan versatility in cell adhesion: a tale of multiple motifs.
Moore et al. Cell Commun. Signal (2010)
Other switches involving participants
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)
Dystroglycan (DAG1) - 3 more (view)
Dystrophin (DMD) - 2 more (view)
Other switches involving interfaces
WW domain - 105 more (view)
SH3 domain - 7 more (view)
LIG_SH3_3 - 5 more (view)
LIG_WW_1 - 17 more (view)
