Description:
Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by Src kinase (Proto-oncogene tyrosine-protein kinase Src (SRC)) switches the specificity of DAG1 from the WW domain containing cytoskeletal linker Dystrophin (DMD) to the SH2 domain containing Tyrosine-protein kinase Fyn (FYN).
Participants:
(1) Dystroglycan (DAG1)
(2) Dystrophin (DMD)
(3) Tyrosine-protein kinase Fyn (FYN)
(1) Dystroglycan versatility in cell adhesion: a tale of multiple motifs.
Moore et al. Cell Commun. Signal (2010)
(2) Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.
Sotgia et al. Biochemistry (2001)
Other switches involving participants
Dystroglycan (DAG1) - 3 more (view)
Tyrosine-protein kinase Fyn (FYN) - 1 more (view)
Dystrophin (DMD) - 2 more (view)
Other switches involving interfaces
SH2 domain - 140 more (view)
WW domain - 105 more (view)
LIG_SH2_SRC - 8 more (view)
LIG_WW_1 - 17 more (view)
