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Here's a minimal first cut at describing Py_DEBUG and
friends.
Hopefully the description is detailed enough to be
useful but not so
detailed as to always be out-of-date. If nothing else,
perhaps it
will spur someone with better knowledge of these
details to correct my
mistakes and flesh out detail.
As is usual for me, I have not run this through LaTeX.
 (I lack it at
work.) It will need to be checked for correctness.
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You know about Misc/SpecialBuilds.txt?

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If I did I forgot. I was grepping around trying to figure
out what Py_DEBUG did exactly and saw the XXX comment
in Doc/api/api.tex. I naively assumed at that point that
Py_DEBUG and friends weren't documented. In any case, I
think it makes sense to have some mention of the available
options in api.tex, simply because it's the "official"
documentation. It should reference Misc/SpecialBuilds.txt
as well.
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I've applied a slightly modified version of your patch in rev. 50948. Good 
work!