概要:Development of form in an embryo is the result of a series of symmetry
breakings starting from topological and informational singularity of
the zygote. Pattern generating reaction-diffusion systems are not
capable of form generation, as they are locally isotropic. We
introduce Vector-Reaction-Diffusion-Drift system based on three new
concepts: source-field coupling, local drift for global symmetry
breaking and vector morphogens as pillars of form. An integrated model
with topological, physical, chemical and regulatory layers is
presented. Simulation of blastula moving into gastrulation shows
realistic form generation as an emergent phenomenon of the ensemble of
locally interacting identical cells. We further expand our model by
introducing Dynamical Cell Differentiation where the regulatory genome
is generalized into a finite-state-machine. This allows symmetry
breakings to be choreographed into sub-spatial domains resulting in
further detailed form generation.