J-GLOBAL ID:200901083991714708 Update date: Jan. 17, 2024

Toh Hiroyuki

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Kwansei Gakuin University School of Science and Technology

Research field (1): Molecular biology

Research keywords (6): 蛋白工学 , バイオインフォマティクス , 分子進化 , protein engineering , bioinformatics , molecular evolution

• タンパク質の機能解析
• Analysis of Protein Function

• Lin Sun, Naoko Kono, Takeyuki Shimizu, Hiroyuki Toh, Hanbing Xue, Osamu Numata, Manabu Ato, Shigeyuki Itamura, Kazuo Ohnishi. Distorted antibody repertoire developed in the absence of pre-B cell receptor formation. Biochemical and Biophysical Research Communications. 2018. 495. 1. 1411-1417
• Naoko Kono, Lin Sun, Hiroyuki Toh, Takeyuki Shimizu, Hanbing Xue, Osamu Numata, Manabu Ato, Kazuo Ohnishi, Shigeyuki Itamura. Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 487. 2. 300-306
• Hiroyuki Oda, Motonori Ota, Hiroyuki Toh. Profile comparison revealed deviation from structural constraint at the positively selected sites. BIOSYSTEMS. 2016. 147. 67-77
• Wataru Nemoto, Yoshihiro Yamanishi, Vachiranee Limviphuvadh, Akira Saito, Hiroyuki Toh. GGIP: Structure and sequence-based GPCR-GPCR interaction pair predictor. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2016. 84. 9. 1224-1233
• Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Junko Okuno, Emi Shimizu, Kenta Kurayoshi, Kazuyuki Kugawa, Hiroyuki Toh, Kiyoshi Ohtani. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts. GENES TO CELLS. 2015. 20. 9. 739-757

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• T Suzuki, K Yamasaki, S Fujita, K Oda, M Iseki, K Yoshida, M Watanabe, H Daiyasu, H Toh, E Asamizu, et al. Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003. 301. 3. 711-717
• Identification of a New Cryptochrome Class: Structure, Function, and Evolution. Molecular Cell. 2003. 11, 59-67
• Deduction of a regulatory network from gene expression data by the application of graphical Gaussian modeling. Signal Processing. 2003. 83, 777-788
• Y Ikema, M Hiyoshi, H Daiyasu, H Toh, M Mori, K Takamune. Two novel genes expressed in Xenopus germ line: Characteristic features of putative protein structures, their gene expression profiles and their possible roles in gametogenesis and embryogenesis. MOLECULAR REPRODUCTION AND DEVELOPMENT. 2002. 62. 4. 421-430
• Inference of a Genetic Network by a Combined Approach of Cluster Analysis and Graphical Gaussian Modeling. Bioinformatics. 2002. 18, 287-297

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• Phylogenetic Footprinting
  Encyclopedia of Bioinformatics and Computational Biology 1st Edition ABC of Bioinformatics (Eds. Ranganathan, S., Nakai, K., Shorbach, C.), Elsevier 2018
• Estimation of Physical Transcriptional Control in Yeast Cell Cycle by Structure Equation Modeling.
  Protein Purification and Analysis I, iConcept Press 2013
• Evoltionary analysis of lipocalin-type prostaglandin D3 synthase.
  prostaglandin D2 synthase - A Multitude of Biological Functions (Ed. Ragolia, L.),Research Signpost, Kerala 2007
• Inference of Protein-Protein Interaction by Using Co-evolutionary Information
  Algebraic Biology - 2nd International Conference, Algebraic Biology 2008 Proceedings - (Eds. Anai, H., Horimoto, K., Kursita T.), Springer, Berlin 2007
• Molecular evolution of proteins involved in the arachidonic acid cascade
  Comprehensive Natural Products Chemistry. (Eds. Barton et al.) Volume I Polyketides and secondary metabolites including fatty acids and their derivatives. Elsevier, Amsterdam 1999

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• PhD (Kyushu University)

• 2015/04 - 現在 Kwansei Gakuin University School of Science and Technology
• 2014/04 - 2015/03 産業技術総合研究所 ゲノム情報研究センター 副研究センター長
• 2010/04 - 2014/03 産業技術総合研究所 生命情報工学研究センター 副研究センター長
• 2005/04 - 2010/03 Kyushu University Medical Institute of Bioregulation
• 2003/04 - 2005/03 Kyoto University Institute for Chemical Research
2002/10 - 2005/03 Kyoto University Institute for Chemical Research
2002/04 - 2002/09 技術研究組合 生物分子工学研究所 生命情報研究部 部長
1999/04 - 2002/03 (株)生物分子工学研究所 情報解析部門 部門長
1996/04 - 1999/03 (株)生物分子工学研究所 情報解析部門 主任研究員
1993/04 - 1996/03 Kyushu Institute of Technology
1989/01 - 1993/03 (株)蛋白工学研究所 第五研究部 研究員

バイオインフォマティクス学会 , 進化学会 , 蛋白質科学会 , 遺伝学会 , 生物物理学会 , 分子生物学会 , The Japanese society of bioinformatics , The society of evolutionary studies , The protein science society of Japan , The biophysical society of Japan , The genetics society of Japan , The molecular biology society of Japan

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