@prefix fhir: . @prefix owl: . @prefix rdfs: . @prefix xsd: . # - resource ------------------------------------------------------------------- [a fhir:DetectedIssue ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "ddi"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "

Severity: High - Risk of internal bleeding

Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding.

Mitigation: Jan 5, 2014 by Dr. Adam Careful:

Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring

" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ; fhir:code [ fhir:v "DRG" ] ; fhir:display [ fhir:v "Drug Interaction Alert" ] ] ) ] ) ; # fhir:code [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ; fhir:code [ fhir:v "DRG" ] ; fhir:display [ fhir:v "Drug Interaction Alert" ] ] ) ] ; # fhir:severity [ fhir:v "high"] ; # fhir:subject [ fhir:reference [ fhir:v "Device/example" ] ] ; # fhir:identified [ fhir:v "2014-01-05"^^xsd:date] ; # fhir:implicated ( [ fhir:reference [ fhir:v "MedicationStatement/example001" ] ; fhir:display [ fhir:v "500 mg Acetaminophen tablet 1/day, PRN since 2010" ] ] [ fhir:reference [ fhir:v "MedicationRequest/medrx0331" ] ; fhir:display [ fhir:v "Warfarin 1 MG TAB prescribed Jan. 15, 2015" ] ] ) ; # fhir:detail [ fhir:v "Risk of internal bleeding. Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding."] ; # fhir:mitigation ( [ fhir:action [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ; fhir:code [ fhir:v "13" ] ; fhir:display [ fhir:v "Stopped Concurrent Therapy" ] ] ) ; fhir:text [ fhir:v "Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring" ] ] ; fhir:date [ fhir:v "2014-01-05"^^xsd:date ] ; fhir:author [ fhir:reference [ fhir:v "Practitioner/example" ] ; fhir:display [ fhir:v "Dr. Adam Careful" ] ] ] )] . # # -------------------------------------------------------------------------------------