ELM - instance TRG_ENDOCYTIC_2 in sequence P19814 at position 350

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001099	P19814 Ttgn1 TGON3_RAT	350	353	RSKVTRRPKASDYQRLNLKL	TP	1BXX pdb:1BXX	Rattus norvegicus (Norway rat)	357

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0114	x-ray crystallography	in vitro	Owen,1998	support	certain	InteractionDetection FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000212:
ELM Switch SWTI000212
Binding of 18348" target="_blank">1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (Ap2m1) subunit for recruitment of Trans-Golgi network integral membrane protein TGN38 (Ttgn1) via an endocytosis motif.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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