ELM - instance TRG_ENDOCYTIC_2 in sequence P03383 at position 477

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001839	P03383 env ENV_HTLV2	477	480	PQRLQNRHNQYSLINPETML	TP	---	Human T-lymphotropic virus 2	486

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0256	rna interference	in vivo	Ilinskaya,2010	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Ilinskaya,2010	support	certain	FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000223:
ELM Switch SWTI000223
Binding of 18348" target="_blank">1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein gp63 (env) via an endocytosis motif.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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