o Instance
| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001540 | P06213 INSR INSR_HUMAN |
993 | 999 | PLGPLYASSNPEYLSASDVF | TP | --- | Homo sapiens (Human) | 1382 |
o Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0018 | two hybrid | in vivo | Gustafson,1995 | support | certain | InteractionDetection |
| experimental | MI:0424 | protein kinase assay | in vitro | Isakoff,1996 | support | certain | InteractionDetection |
| experimental | MI:0018 | two hybrid | in vivo | Isakoff,1996 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Isakoff,1996 | support | certain | FeatureDetection |
o Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P35568) IRS1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
160 | 262 | [mitab] [xml] | |
| (Q9Y4H2) IRS2_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
194 | 296 | [mitab] [xml] | |
| (P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab] [xml] |
o Switches
o Pathways
KEGG: The sequence P06213 is implicated in the following 22 Pathways: (color codes: This sequence=red, interacting sequence=orange)o Diseases