ELM - instance DEG_SCF_TRCP1_1 in sequence P19838 at position 926

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001306	P19838 NFKB1 NFKB1_HUMAN	926	932	DSDSVCDSGVETSFRKLSFT	TP	---	Homo sapiens (Human)	968

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0405	competition binding	in vitro	Lang,2003	support	likely	InteractionDetection
experimental	MI:0424	protein kinase assay	in vitro	Lang,2003	support	certain	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000162:
ELM Switch SWTI000162
Dual phosphorylation of S927 and S932 in the TrCP1-binding motif of Nuclear factor NF-kappa-B p105 subunit (NFKB1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

o Pathways

KEGG: The sequence P19838 is implicated in the following 75 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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