ELM - Detail for MOD

Accession:	ELME000162
Functional site class:	O-Fucosylation site
Functional site description:	Site for attachment of a fucose residue to a serine
ELM Description:	Site for attachment of a fucose residue to a serine
Pattern:	`C.{3,5}([ST])C`
Pattern Probability:	`0.0000462`
Present in taxons:	Caenorhabditis elegans Drosophila melanogaster Eumetazoa Homo sapiens Mus musculus
Interaction Domain:	O-FucT (PF10250) GDP-fucose protein O-fucosyltransferase (Stochiometry: 1 : 1)

o Abstract

O-Fucose modifications have been described in several different protein contexts including epidermal growth factor-like repeats (important players in several signal transduction systems) and thrombospondin type 1 repeats (in a region involved in cell adhesion). In Notch, a cell-surface signaling receptor required for many developmental events, the O-fucose moieties serve as a substrate for the activity of Fringe, a known modifier of Notch function.

o 1 selected reference:

O-fucose modifications of epidermal growth factor-like repeats and thrombospondin type 1 repeats: unusual modifications in unusual places.
Shao L, Haltiwanger RS
Cell Mol Life Sci 2003 Feb; 60 (2), 241-50
PMID: 12678489

o 1 GO-Term:

Cellular Compartment:
Extracellular (also annotated in these classes: CLV_MEL_PAP_1 CLV_NRD_NRD_1 CLV_PCSK_FUR_1 CLV_PCSK_KEX2_1 CLV_PCSK_PC1ET2_1 CLV_PCSK_PC7_1 CLV_PCSK_SKI1_1 LIG_FXI_DFP_1 LIG_Integrin_collagen_1 LIG_Integrin_isoDGR_2 LIG_Integrin_KxxGD_FGGC_5 LIG_Integrin_RGD_1 LIG_Integrin_RGDSP_6 LIG_Integrin_RGD_TGFB_3 LIG_Integrin_RGDW_4 LIG_LRP6_Inhibitor_1 LIG_NRP_CendR_1 LIG_WSXWS MOD_ASX_betaOH_EGF MOD_CMANNOS MOD_Cter_Amidation MOD_GlcNHglycan MOD_N-GLC_1 MOD_N-GLC_2 MOD_OGLYCOS MOD_WntLipid TRG_Oom_RxLR_1 TRG_Pf-PMV_PEXEL_1 )

Cellular Compartment:

Extracellular (also annotated in these classes: CLV_MEL_PAP_1 CLV_NRD_NRD_1 CLV_PCSK_FUR_1 CLV_PCSK_KEX2_1 CLV_PCSK_PC1ET2_1 CLV_PCSK_PC7_1 CLV_PCSK_SKI1_1 LIG_FXI_DFP_1 LIG_Integrin_collagen_1 LIG_Integrin_isoDGR_2 LIG_Integrin_KxxGD_FGGC_5 LIG_Integrin_RGD_1 LIG_Integrin_RGDSP_6 LIG_Integrin_RGD_TGFB_3 LIG_Integrin_RGDW_4 LIG_LRP6_Inhibitor_1 LIG_NRP_CendR_1 LIG_WSXWS MOD_ASX_betaOH_EGF MOD_CMANNOS MOD_Cter_Amidation MOD_GlcNHglycan MOD_N-GLC_1 MOD_N-GLC_2 MOD_OGLYCOS MOD_WntLipid TRG_Oom_RxLR_1 TRG_Pf-PMV_PEXEL_1 )

o 4 Instances for MOD_OFUCOSY
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)

Acc., Gene-, Name	Start	End	Subsequence	Logic	#Ev.	Organism
P98119 Salivary plas URT1_DESRO	92	98	SCSEPRCFNGGTCWQAVYFS	TP	1	Desmodus rotundus (Common vampire bat)
P00750 PLAT TPA_HUMAN	291	296	RRLTWEYCDVPSCSTCGLRQ	FP	1	Homo sapiens (Human)
P00750 PLAT TPA_HUMAN	91	97	SCSEPRCFNGGTCQQALYFS	TP	1	Homo sapiens (Human)
P00749 PLAU UROK_HUMAN	33	39	VPSNCDCLNGGTCVSNKYFS	TP	1	Homo sapiens (Human)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement

feedback@elm.eu.org