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metallopeptidase activity

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Term Information

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Accession
GO:0008237
Name
metallopeptidase activity
Ontology
molecular_function
Synonyms
metalloprotease activity, metalloproteinase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment
None
History
See term history for GO:0008237 at QuickGO
Chem. react.
None
Subset
None
Link to all genes and gene products annotated to metallopeptidase activity (excluding "regulates").
Link to all direct and indirect annotations to metallopeptidase activity (excluding "regulates").
Link to all direct and indirect annotations download (limited to first 10,000) for metallopeptidase activity (excluding "regulates").
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0008237 from QuickGO

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Parents of metallopeptidase activity (GO:0008237)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metallopeptidase activity [is_a relation] is_a peptidase activity (GO:0008233)
Children of metallopeptidase activity (GO:0008237)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of metallopeptidase activity (GO:1905049) [RO:0002212 relation] RO:0002212 metallopeptidase activity
metalloendopeptidase activity (GO:0004222) [is_a relation] is_a metallopeptidase activity
positive regulation of metallopeptidase activity (GO:1905050) [RO:0002213 relation] RO:0002213 metallopeptidase activity
regulation of metallopeptidase activity (GO:1905048) [RO:0002211 relation] RO:0002211 metallopeptidase activity
metal-dependent deubiquitinase activity (GO:0140492) [is_a relation] is_a metallopeptidase activity
metalloexopeptidase activity (GO:0008235) [is_a relation] is_a metallopeptidase activity
metal-dependent deNEDDylase activity (GO:0140758) [is_a relation] is_a metallopeptidase activity
H-gal-GP complex (GO:1990850) [RO:0002215 relation] RO:0002215 metallopeptidase activity

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